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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
ERCC6
All Species:
14.55
Human Site:
Y642
Identified Species:
26.67
UniProt:
Q03468
Number Species:
12
Phosphosite Substitution
Charge Score:
0.17
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q03468
NP_000115.1
1493
168416
Y642
I
S
R
Y
D
W
H
Y
V
I
L
D
E
G
H
Chimpanzee
Pan troglodytes
XP_507781
1491
168031
Y640
I
S
R
Y
D
W
H
Y
V
I
L
D
E
G
H
Rhesus Macaque
Macaca mulatta
XP_001107536
1496
168876
Y645
I
S
R
Y
D
W
H
Y
V
I
L
D
E
G
H
Dog
Lupus familis
XP_534944
1486
168108
Y638
I
S
R
H
D
W
H
Y
V
I
L
D
E
G
H
Cat
Felis silvestris
Mouse
Mus musculus
Rat
Rattus norvegicus
NP_001100766
1325
148468
G520
V
A
I
L
H
E
T
G
S
C
A
H
R
K
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508174
968
109820
G163
E
L
H
C
Q
Q
A
G
G
I
L
G
D
E
M
Chicken
Gallus gallus
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q24368
1027
118855
D221
T
R
N
T
F
I
R
D
V
L
M
P
G
E
W
Honey Bee
Apis mellifera
XP_001120586
932
107557
I127
K
L
Y
K
Y
Q
K
I
S
V
Q
W
L
W
E
Nematode Worm
Caenorhab. elegans
P41877
1009
116656
C204
A
N
E
F
K
K
W
C
P
S
I
N
A
V
V
Sea Urchin
Strong. purpuratus
XP_001193315
953
107227
T148
R
N
P
D
A
E
V
T
L
A
C
K
Q
F
R
Poplar Tree
Populus trichocarpa
XP_002307656
1206
134941
V399
F
D
Y
Q
K
V
G
V
Q
W
L
W
E
L
H
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q8RWY3
1057
122611
N252
A
P
K
S
T
L
G
N
W
M
N
E
I
R
R
Baker's Yeast
Sacchar. cerevisiae
P40352
1085
124509
D280
R
P
H
P
N
I
P
D
A
K
L
N
S
Q
F
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.3
97.2
83.3
N.A.
N.A.
70.1
N.A.
44.6
N.A.
N.A.
N.A.
N.A.
20
31.4
20.6
36.4
Protein Similarity:
100
99.4
97.9
89.1
N.A.
N.A.
76.4
N.A.
52.2
N.A.
N.A.
N.A.
N.A.
35.7
43.8
35.7
45.8
P-Site Identity:
100
100
100
93.3
N.A.
N.A.
0
N.A.
13.3
N.A.
N.A.
N.A.
N.A.
6.6
0
0
0
P-Site Similarity:
100
100
100
100
N.A.
N.A.
13.3
N.A.
20
N.A.
N.A.
N.A.
N.A.
20
6.6
26.6
20
Percent
Protein Identity:
29.4
N.A.
N.A.
23.5
28.4
N.A.
Protein Similarity:
44.9
N.A.
N.A.
38.2
43.9
N.A.
P-Site Identity:
20
N.A.
N.A.
0
6.6
N.A.
P-Site Similarity:
20
N.A.
N.A.
20
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
16
8
0
0
8
0
8
0
8
8
8
0
8
0
0
% A
% Cys:
0
0
0
8
0
0
0
8
0
8
8
0
0
0
0
% C
% Asp:
0
8
0
8
31
0
0
16
0
0
0
31
8
0
0
% D
% Glu:
8
0
8
0
0
16
0
0
0
0
0
8
39
16
16
% E
% Phe:
8
0
0
8
8
0
0
0
0
0
0
0
0
8
8
% F
% Gly:
0
0
0
0
0
0
16
16
8
0
0
8
8
31
0
% G
% His:
0
0
16
8
8
0
31
0
0
0
0
8
0
0
39
% H
% Ile:
31
0
8
0
0
16
0
8
0
39
8
0
8
0
0
% I
% Lys:
8
0
8
8
16
8
8
0
0
8
0
8
0
8
0
% K
% Leu:
0
16
0
8
0
8
0
0
8
8
54
0
8
8
0
% L
% Met:
0
0
0
0
0
0
0
0
0
8
8
0
0
0
8
% M
% Asn:
0
16
8
0
8
0
0
8
0
0
8
16
0
0
0
% N
% Pro:
0
16
8
8
0
0
8
0
8
0
0
8
0
0
0
% P
% Gln:
0
0
0
8
8
16
0
0
8
0
8
0
8
8
0
% Q
% Arg:
16
8
31
0
0
0
8
0
0
0
0
0
8
8
16
% R
% Ser:
0
31
0
8
0
0
0
0
16
8
0
0
8
0
0
% S
% Thr:
8
0
0
8
8
0
8
8
0
0
0
0
0
0
0
% T
% Val:
8
0
0
0
0
8
8
8
39
8
0
0
0
8
8
% V
% Trp:
0
0
0
0
0
31
8
0
8
8
0
16
0
8
8
% W
% Tyr:
0
0
16
24
8
0
0
31
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _